Would you add chemotherapy to IO in the setting of low volume disease metastatic Adenocarcinoma of the lung with PDL-1 80%?
Judgement call as "low volume" disease is a subjective assessment. If patient were significantly symptomatic that would sway me to use combined chemo-IO. The PD-L1 of 80% is intermediate in my mind. Much of the decision is the degree of disease volume and symptoms. In general, I have a low threshold for chemo-IO as ORR are about 20-25% higher compared O monotherapy.