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NHL | Age 78 | New Dx
Non-Hodgkin Lymphoma Specialist
I have a new diagnosis of Mantle Cell Lymphoma in a 78 year old, who has extensive disease burden in lymph node, skeleton. He is high risk per MIPI although LDH is normal. I dont know about p53 status [never checked] and or morphology of MCL. We have a clinical trial open, with Rituximab and Zanubrutinib. I worry with disease burden, it will be difficult to give rituximab with standard premeds of Tylenol and Benadryl. Would you agree to it?
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GU | Age 76 | New Dx
GU Cancer Specialist
76 year old ECOG 1 patient with multiple cardiac comorbidities with a high grade papillary urothelial carcinoma of the renal pelvis. It measured 7x11 mm on CT imaging as a filling defect. She had a R ureteroscopy which again characterized high grade non-invasive urothelial carcinoma without muscularis propria visible. She is queued up for a nephro-ureterectomy with the question for role of neoadjuvant chemo. Questions: 1. Do you typically aim for a neoadjuvant approach if patients are functional?
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GI Cancer
GI Cancer Specialist
Just a general principle question. In anal cancer metastatic to liver, I used carboplatin and paclitaxel with good responce after 6 cycles. How long can you continue these chemo? Is there a limit to number of cycles? Or role of chemo holiday? Going to one of the chemo? Or stopping after certain fixed amount of cycles?
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Breast | Age 43 | New Dx
Breast Cancer Specialist
I have a 43 year old premenopausal woman with de novo Stage 4 Triple Positive Breast Cancer (ER/PR 70%, HER 2 3+) with brain and lung mets. Got SBRT to brain for lesions. Now starting docetaxel plus dual her2. What is your approach to endocrine therapy and ovarian suppression in this setting?
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Lung | Age 80
Lung Cancer Specialist
80yr female, ECOG 0 with stage IV EGFR exon 21 L 858R lung adeno, PDL1 5%. Just completed palliative RT for painful right chest wall lesion. Would you use osimertinib alone or with carbo/Pem?
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H&N | Age 58 | R/R
Head and Neck Cancer Specialist
58 year old female with SCC of supraglottic larynx, initially diagnosed as T2N0M0 received RT, total laryngectomy, then concurrent cisplatin+RT on local recurrence. Patient then progressed so started pembro but patient is experiencing clinical and radiographic progression. Is cetuximab my next best option?
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