Lung Cancer | Age 69 | New Dx

Would you offer Osmertinib for resected Adeno EGFR exon 19 (AJCC 8TH EDITION): pT2a pN0 based on pleural invasion with size of 1.8 cm after Chemotherapy with neg ctDNA after surgery?

MDS/MPN | Age 65

65M w/ MDS/MPN-unspecified (5-10% blasts on marrow, normal karyotype but 7 tier 1 molecular lesions). Not a transplant candidate. He has a very proliferative phenotype. Symptoms have improved with hydrea and then 2 rounds of decitabine but he has become transfusion dependent (1-2 pRBCs/week), WBC remains >80k, and repeat marrow is unchanged with >95% cellularity and 8% blasts. Do you think Ven/Aza is appropriate?

Lung Cancer | Age 59

I have 59 M with Metastatic Squamous cell Lung cancer with PDL1 90%. plan to proceed with IO alone. Any preference among the 4 immunotherapy approvals for Squam?

Classical Hematology

Myeloma patient off treatment due to severe recurrent UTI's, AKI, poor PS who is now ready to resume therapy. Her Hb is 7.7, GFR 29, iron sat 12%, ferritin 1400 (likely had UTI at the time). Would you proceed with IV iron even with such an elevated ferritin?

Breast Cancer | Age 78 | R/R

78 yo female with metastatic triple negative breast cancer. Recently, pulmonary metastasis is progressing. Biopsy positive for TNBC with PD-L1 100%. What are your thoughts on single agent keytruda?

Multiple Myeloma

I have an 80y old with new diagnosis of smoldering myeloma (15% plasma cells), no CRAB but KLR 0.08. She also has RA and her Rheum would like to start rituxan and low dose MTX. 1. Is it ok to go ahead with rituxan? 2. Would treating the myeloma help the RA. Thoughts?